UC San Francisco researchers develop inside-the-body CAR-T cell engineering

Scientists have created a technique to reprogram T cells inside the body, eliminating the costly and slow process of modifying immune cells in a laboratory.

HEROIC BREAKING NEWS, written by our newsroom7 October 2026 at 14:160 views

Scientists at UC San Francisco have developed a method to create cancer-fighting CAR-T cells directly inside the human body, ScienceDaily reported. The novel approach aims to replace the current process of removing, modifying, and reinfusing a patient's immune cells. [1]

According to ScienceDaily, the researchers used a two-particle delivery system to deliver gene-editing tools and cancer-targeting DNA into T cells. The delivery mechanism utilizes CRISPR technology to edit the immune cells inside the patient. [1]

ScienceDaily reported that existing CAR-T cell therapies have transformed treatments for specific blood cancers. However, traditional methods require sending a patient's immune cells to specialized facilities, making the overall process slow and extremely expensive. [1]

The new delivery system could potentially streamline cancer treatment by making CAR-T therapies faster and easier to administer to patients, according to ScienceDaily. [1]

UC San Francisco researchers engineered CAR-T cells directly inside the body using CRISPR tools.
The process uses a two-particle system to deliver cancer-targeting DNA to T cells.
Traditional CAR-T cell therapy requires removing immune cells and sending them to specialized laboratories.

Sources

Every paragraph above points to the numbered items it rests on. Read the originals here.

[1]Scientists reprogram immune cells inside the body to fight cancerScienceDaily, 5h ago (the report this story comes from)

Background

[2]Plant disease resistance on Wikipedia

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